Changes in your blood can reveal cancer 13 years before it develops

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Title : Changes in your blood can reveal cancer 13 years before it develops
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Changes in your blood can reveal cancer 13 years before it develops

by Fiona Macdonald
ScienceAlert

This could be the initial advantage we need to beat the disease.

A new study has shown there are small genetic changes that occur in our cells over a decade before cancer is diagnosed, and can be detected through a simple blood test.

the research found that there are changes in the duration our telomeres - the protective end of our chromosomes that shrink with age tapas - you can predict cancer up to 13 years before symptoms develop, and could help to detect and combat the disease in its earliest stages.


This is the first study to monitor changes progressively telomeres in people over a long period of time, and it shows that there is a unique pattern in the length of telomeres predicts will happen to develop the disease.

"understanding this pattern of growth telomeres may mean that it can be a predictive cancer "biomarker, the study's lead author, Hou Lifang Northwestern University in the US, said in a statement press . "Because we have seen a strong relationship in the pattern across a wide variety of cancers, with the right to test these procedures could be used to diagnose, finally, a wide variety of cancers."

researchers have been trying to understand the link between telomere length and cancer for years, but so far they have struggled to reach a consistent result.

to investigate further, the researchers followed 792 apparently healthy people between 1999 and 2012. at the end of the study, 135 of these participants were diagnosed with a variety of cancers, including prostate, skin, lung and leukemia. Looking back at their records, the researchers found they could say that would develop cancer just by looking at the pattern of changes in blood cell telomere length, which is considered a marker of biological age.

from the outset, the telomeres of those who would go on to be diagnosed with cancer was reduced much faster, meaning they were aging faster than those who did not develop cancer. In fact, the telomeres of future cancer patients seemed much as 15 years longer than their peers.

But this process of accelerated aging stopped three or four years before being diagnosed with cancer, which could explain why previous research has struggled to find a clear link between telomere length and cancer diagnosis.

the results also provide important information about how cancer appropriates our cells . As part of the natural aging process, every time our cells divide, our telomeres shrink. After a certain number of cell divisions, the telomeres become so short that cells become inactive or self-destruction, while being replaced by younger and more healthy cells. But it is now clear that the cancer has found a way to get around this guarantee in order to make our cells replicate uncontrollably.

"We saw the turning point where it stabilizes the rapid telomere shortening, " said Hou . "We found the cancer has kidnapped telomere shortening in order to thrive in the body." The team's findings have been published in Journal EBioMedicine .

The next step for researchers is to find a reliable method to detect this pattern of changes in telomere length. If we can achieve this, we may be able to detect signs of cancer before they ever have the opportunity to replicate without checking in our body. And do not become far ahead of ourselves, but it could really be a turning point in the war against cancer. Bring it on.

"Changes in your blood can reveal cancer 13 years before it develops", article source: riseearth.com


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