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Title : New cancer 'wonder' drugs trigger cancer spread to bones
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New cancer 'wonder' drugs trigger cancer spread to bones

Most anticancer drugs are used to kill tumors and hopefully prevent the spread of malignancies. Unfortunately, new research from the University of Washington School of Medicine in St. Louis raises serious concerns that highly touted class of large pharmaceutical companies of cancer drugs known as IAP antagonists actually increases the risk of spread of tumors of bone.

"These investigational drugs are receiving widespread attention at this time, as they seem to be very effective against primary tumors," lead author Deborah V. Novack, MD, PhD, associate professor medicine, said in a press release "there is also excitement because until now, these drugs have not appeared to have significant side effects."

However, the study by Novack and his research team (recently published in the journal Cancer Discovery) reveals that while IAP drugs target a protein that makes tumors vulnerable to death, the same protein also overactive cells called osteoclasts are responsible for bone tear down. The risk for patients? Potentially, IAP can trigger osteoporosis disease weakened bones and even more worrying, can cause cancer metastases to bone.

Numerous antagonists IAP are already in the first clinical trials against breast, lung, pancreatic, ovarian, prostate, liver, skin and blood cancers. While these stages one or two clinical trials looking at the safety and efficacy of new drugs in the short term, researchers say they can not take bone metastases. "These tests do not necessarily seek long-term effects of drugs," Yang Chang, MD, PhD, said plant scientist and first author of the article in the press release. "If the cancer is going to metastasize to bone, can take six months to two years to see this result. This can not be seen during the clinical trial."

Because the study findings, Novack has recorded urging specialists oncologists consider protecting bones in people taking antagonists IAP cancer, including patients with cancers that usually not spread to the bones. "For many of these cancers, doctors are not seeing the bones," says Novack. "Osteoporosis is not a major concern in the treatment of cancer, but if they are not doing bone scan, which may miss a cancer that spreads to the bones."

Normally, osteoclasts work together other normal cells to build new bone. But because IAP antagonists on-activating osteoclasts
bone ends up being destroyed and not replaced. Working with mice experiments, the scientists showed that the drug led to osteoporosis and created an environment that encourages tumor growth in degrading bone, even while killing the cells of breast cancer in other body parts of the animals.

Natural News As previously reported, also found other anticancer drugs to possibly promote disease that is supposed to fight. For example, according to findings published in the Proceedings of the National Academy of Sciences researchers at the George Whipple Laboratory for Cancer Research at the University of Rochester Medical Center, hormone therapy for prostate cancer can cause an acceleration of other cell growth and prostate lead to proliferation of cancer cells in the future. In addition, researchers at the University of Alabama at Birmingham Comprehensive Cancer Center (UAB) and the Department of Chemistry of the UAB a grant of $ 805,000 from the Department of Defense Breast Cancer Research Program awarded US in 2010. The goal? . To investigate the very real possibility that the dead cancer cells left after cancer chemotherapy spark spread to other parts of the body

Editor's note: Natural News opposes use of animals in medical experiments that expose them to harm. We present these findings in protest at the way they were acquired

sources article.
http://news.wustl.edu/news/Pages/24916 .aspx
http://www.naturalnews.com/034099_prostate_cancer_treatments.html
http://www.naturalnews.com/029042_cancer_cells_chemotherapy.html

About the author:
Sherry Baker is a widely published writer whose work has appeared in Newsweek, health, the Atlanta journal Constitution, Yoga journal, optometry, Atlanta, arthritis today, Natural Healing newsletter, OMNI, newsletter UCLA "healthy life years", Mount Sinai School of Medicine of "Focus on Aging Health" newsletter, newsletter "Health Advisory Men" of the Cleveland Clinic and many . others
Source: NaturalNews.com

"New cancer 'wonder' drugs trigger cancer spread to bones", article source: riseearth.com

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