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Title : Revolutionary New Cell Type May Hold Key To Treating Heart Failure
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Revolutionary New Cell Type May Hold Key To Treating Heart Failure

id = " Around 610,000 people die of heart disease in the US every year - that's one out of every four deaths. It is proving to be a particularly difficult medical problem :. Heart damage is usually irreversible, because heart cells can not regenerate themselves This crippling lack of regeneration, however, may soon be a thing of the past, as researchers have discovered how to make a remarkable new type of cell that can allow hearts to repair themselves. The new study, published in the journal Cell Stem Cell reveals that these transplantable cells are produced using a revolutionary new technique that allows researchers to temporarily "freeze" a stem cell in its development. Heart failure (HF), in which the heart is overworked or supply of oxygenated blood is too low, causing a huge loss of heart muscle cells known as cardiomyocytes (CMS). "You lose at least a billion heart cells in a heart attack," Dr. Sheng Ding, a professor at the Gladstone Institute of Cardiovascular Diseases and coordinating author of the study, said IFLScience. Not only can not be these CMs regenerated by the heart , but can not even be replaced by the new CM injected. "Transplanted new heart cells in the patient's heart will not survive - within a day or two, most have been lost." Ding said team Ding believes that a possible way to overcome this problem is the use of cells called "stem cells". Although similar to a pluripotent stem cells, which can develop into any cell found in the human body, these progenitor cells differ a little, ie already programmed to become a specific target cell -. including heart cells cardiovascular progenitor cells (CPC) occur naturally as the heart is formed in the embryo, and will form all heart cell types required, including CM. The use of a cocktail of pharmaceutical drugs, which were able to produce these CPC in the laboratory from stem cells, arresting their natural development in heart cells fully operational. These lab-made cells known as "induced CPC expandable." Not only can induce these new CPC to become heart cells, but they can replicate indefinitely, which means that potentially damaged hearts can be injected with biological material self-repair. In order to test their theory, a solution containing these CPC - "tied" to become various cell types of the heart -. They were injected into a mouse after suffering a heart attack Incredibly, 90 percent of these new cells spontaneously transformed into functioning heart cells, the creation of new blood vessels and generating new muscle tissue. Compared with injection mother cells, which require a complex series of signals to begin developing into heart cells, this is a great improvement. Cardiac function was improved in the mouse for at least three months. Like the original stem cells are obtained from skin cells, this raises a tantalizing future possibility. Cells from the patient's own skin could be used to treat your own heart disease "My prediction is that in the next couple of years we will be able to make human CPC in a very similar way, "Sheng said. "Human trials will continue after that."

Source: http: //www.iflscience.com/

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