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Title : Scientists Discover How High-Fat Diets Can Cause Cancer
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Scientists Discover How High-Fat Diets Can Cause Cancer

id = " often comes hand in hand, both obesity and a high fat diet have been linked to an increased risk of several different types of cancer . Although there have been proposed several possible mechanisms to explain such associations, scientists have been kept in the dark about how these risk factors could lead to colon cancer. However, a new study finally seems to offer some answers, finding that a diet high in fat increases the growth of stem cells in the intestine of mice and may increase the likelihood that other form tumors. This finding actually connects very well with previous studies that found that these intestinal stem (SICS) cells represent the population this area is most likely to accumulate potentially cancerous mutations driving. This observation makes sense given the fact that stem cells can divide indefinitely effectively, resulting in a lot of different types of cells that make up the various tissues and organs. So if a mutation occurs in one of these cells, it is more likely to hang around. To learn more about your relationship with obesity and colon cancer, researchers from the US mice maintained on a high fat diet long term consisting of 60 percent fat; Western diets usually consist of around 20 to 40 percent. It is described in Nature , these mice not only earn significantly more weight than their normal counterparts Chow-fed, there were also marked differences in their intestines. In particular, there was a significant increase in the number of CSI in mice with a high-fat diet, despite the fact that there was actually a decrease in the number of specialized cells called cells Paneth, constituting the intestinal lining. Can diets high in sugar also trigger the same changes? Alexandra Lande / Shutterstock then wanted to see if this diet could improve the regenerative capacity of the intestine, so the CSI of the mice were removed and they grew up on a plate. Those obtained from mice in a miniature versions high fat diet made up of the intestines much more easily than those taken from control mice, the researchers found was down to the activation of a molecule called PPAR-delta. "PPAR-delta is a master of fatty acid metabolism regulator, which allows cells to use fatty acids for energy," lead researcher Omer Yilmaz, the Institute of Technology of Massachusetts said IFLScience. "But what is really exciting is that, besides this, we found that PPAR-delta involves a set of genes that are important for stem cell identity." As evidence of this, in mice on a high fat diet, activation of PPAR-delta in intestinal stem cells - daughters of stem cells found along the path of specialization - caused to behave like stem cells, which increases its life and giving them the ability to form mini-intestines on a plate. Importantly, when the computer deletes a gene in these cells often mutated in colon cancer cells obtained from the ability to form tumors. "previously been shown that if this gene is deleted in stem cells, which results in tumors," said Yilmaz IFLScience. "But if released into the cells mother, who rarely gets tumors." So it is not only the high fat diet by increasing the number of stem cells, and hence the number of target cells can accumulate mutations driving cancer, but also increases the number of cells can undergo tumor formation, said Yilmaz. While humans and mice are not the same, and high-fat diets are not the only diet-related obesity, work is important, however. Ultimately, it may be possible to target PPAR-delta in tumors in obese patients as a potential therapeutic strategy, something researchers are actively working on

Source :. Http: //www.iflscience.com/

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