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Title : Fluoride & the Pineal Gland
link : Fluoride & the Pineal Gland

Fluoride & the Pineal Gland

Sum - Fluoride and Pineal:

Until the 1990s, had never conducted any investigation to determine the impact of fluoride on the pineal gland - a small gland located between the two hemispheres of the brain that regulates the production of the hormone melatonin. Melatonin is a hormone that helps regulate the onset of puberty and helps protect the body against cell damage caused by free radicals

now known -. Thanks to the meticulous research of Dr . Jennifer Lucas from the University of Surrey in England - that the pineal gland is the main objective of the accumulation of fluoride in the body

the soft tissues [ pineal gland adult contains more fluoride than any other soft tissue in the body -. a level of fluoride (~ 300 ppm) capable of inhibiting enzymes

the pineal gland also contains hard tissue (hyroxyapatite crystals), and this hard tissue accumulates more fluoride (up to 21,000 ppm) than any other hard tissue in the body (eg, teeth and bones ).

After discovering that the pineal gland is an important target for the accumulation of fluoride in humans, Dr. Luke conducted experiments animals to determine if the accumulated fluoride could affect the operation of the gland - particulalry regulation gland melatonin

Lucas found that animals treated with fluoride had lower levels of circulating melatonin, as reflected in reduced levels of melatonin metabolites in. animal urine. This reduced level of circulating melatonin was accompanied - as expected -. For a earlier onset of puberty in animals treated with female fluoride

Lucas summarizes its findings in humans and animals as follows:

"in conclusion, the human pineal gland contains the highest concentration of fluoride in the body. fluoride is associated with the synthesis of the pineal melatonin depressed by gerbils prepubertal and start accelerated sexual maturation in the female gerbil. the results strengthen the hypothesis that the pineal has a role in the time of onset of puberty. whether or not fluoride interferes with pineal function in humans requires further investigation. "

Documents Online - fluoride and the Pineal:

FULL TEXT - html: Lucas J. (2001). fluoride deposition in aged human pineal gland. Caries Research. 35: 125-128

PDF Full text: • Lucas J. (1997). Doctoral Thesis: The effect of fluoride on the physiology of the pineal gland (298 pages)

EXTRACT - html: Lucas J. (1997) . The effect of fluoride on the physiology of the pineal gland. Phd. in Philosophy. Thesis. . University of Surrey, Guildford

Items - Fluoride and Pineal:

fluoride and the Pineal: study published in Caries Research Bulletin IFIN, March 2001

fluoride and Oxidative Stress: further evidence FAN Science Watch 30 September, 2004

Sum - fluoride and pineal:

"the animal study only function pineal indicates that the results of fluoride exposure in the production of altered melatonin and the time of sexual maturity altered Yes. fluoride affects pineal function in humans remains to be demonstrated. the two studies age of menarche in humans show the possibility of menarche earlier in some individuals exposed to fluoride, but no definitive statement can be made. recent information on the role of the pineal organ in humans it suggests that any agent that affects pineal function could affect human health in a variety of ways, including effects on sexual maturation, calcium metabolism, parathyroid function, postmenopausal osteoporosis, cancer and psychiatric illness. "
SOURCE:.. Superior Council for Scientific Research (2006) fluoride in drinking water: A Scientific Review of EPA standards National Academies Press, Washington DC p221-22

"in conclusion, the human pineal gland contains the highest concentration of fluoride in the body. Fluoride is associated with pineal melatonin synthesis by prepubertal gerbils depressed and accelerated onset of sexual maturation in the female gerbil. The results strengthen the hypothesis that the pineal has a role in the time of onset of puberty. . Whether or not fluoride interferes with pineal function in humans requires further investigation "
SOURCE: Lucas J. (1997) The effect of fluoride on the physiology of the pineal gland Doctor of Philosophy... thesis, University of Surrey, Guildford p 177.

fluoride and pineal - never been studied before 1990:...

"it is remarkable that the pineal gland has never been analyzed separately for F, as it has several characteristics that suggest it could accumulate F. has calcium concentration higher than any normal soft tissue in the body, as it is calcified physiologically in the form of hydroxyapatite (hA) has a high metabolic activity along with a very profuse blood supply: .. two factors that favor the deposition of F in mineralizing tissues is the fact that the pineal is outside the blood-brain barrier it suggests that pineal hA could sequester F of the bloodstream if you have the same strong affinity for F as in the other mineralizing tissues. the intensity of the toxic effects of most drugs depends on their concentration at the site of action. mineralizing tissues (bones and teeth) high concentrations of F accumulate and are the first to show toxic reactions to F. therefore their reactions to F have been particularly well studied. If F accumulates in the pineal gland, then this points to a gap in our knowledge about whether or not F affects pineal physiology. Was the lack of knowledge in this area that led to my study. "
SOURCE: Lucas J. (1997) The effect of fluoride on the physiology of the pineal gland Ph.D. Thesis, University of Surrey, Guildford p 02.01 [

fluoride and Pineal Gland - accumulation of fluoride in the soft tissue of the pineal gland

"After half a century of prophylactic use of fluorides in dentistry, we now know that fluoride is readily accumulates in the human pineal gland. In fact, the pineal gland contains more fluoride age than any other normal soft tissue. The concentration of fluoride in the pineal gland was significantly higher (p <0 .001=".001" 0.4="0.4" 0.5="0.5" 257="257" 296="296" br="br" corresponding="corresponding" i.e.="i.e." in="in" kg="kg" mg="mg" muscle="muscle" respectively.="respectively." than="than" vs.="vs." weight="weight" wet="wet">. SOURCE: Luke J. (1997) The effect of fluoride on the pineal gland physiology Ph.D. Thesis University... Surrey, Guildford p 167.

fluoride and Pineal - the accumulation of calcified tissue fluoride in the pineal gland..

"in terms of tissue mineralized, the fluoride concentration in the medium calcification pineal was equivalent to that of the upper severely fluorosed and more than four times bones to corresponding bone ash, ie, 8.900 ± 7.700 vs 2.040 ± 1.100 mg / kg, respectively . the calcification in two of the 11 pineals analyzed in this study contained extremely high levels of fluoride :. 21,800 and 20,500 mg / kg "
. SOURCE: Luke J. (1997) the effect of fluoride on the physiology pineal gland . Doctor of Philosophy. Thesis. University of Surrey, Guildford. p. 167.

fluoride and Pineal - analogous to dental fluorosis

"Fluoride is now introduced at a much earlier stage of human development than ever and, consequently alters the normal pharmacokinetics fluorides in infants. But one can dramatically increase the normal fluoride intake for babies and get away with it? the safety of the use of fluorides ultimately is based on the assumption that the body of developing enamel is more sensitive to the toxic effects of fluoride. the results of this study suggest that pinealocitos can be as susceptible to fluoride as developing enamel organ ".
SOURCE: Luke J. (1997). The effect of fluoride on the physiology of the pineal gland. Phd. in Philosophy. Thesis. University of Surrey, Guildford. p. 176.

"Together with calcification in the developing enamel organ , calcification also is occurring in pineal child. It is a normal physiological process. A complex series of enzymatic reactions within pinealocitos converts the essential amino acid tryptophan, an entire family of indoles. the main pineal hormone is melatonin (MT) ... If F accumulates in the pineal gland during early childhood, which could affect the indole metabolism . pineal in much the same way that high local concentrations of F in enamel organ and bone metabolism affects ameloblasts and osteoblasts "
SOURCE: Lucas J. (1997). The effect of fluoride on the physiology of the pineal gland. Phd. in Philosophy. Thesis. University of Surrey, Guildford. p. 5.

"Any adverse physiological effects fluoride concentration dependent in different tissue sites. Pinealocitos function can normally in close proximity to high concentrations of fluoride? It would predict that a high concentration of fluoride would affect Local function pinealocyte analogously to a high local concentration of fluoride affects: i) bone cells because histologic changes were observed in bone with 2000 mg F kg (Baud et al, 1978) / ii) ameloblasts, from dental fluorosis develops following fluoride concentrations of 0.2 mg F / kg in the developing enamel organ (Bawden et al, 1992). the consequences are changes in functions bones and enamel, ie, changes in the structure (poorly mineralized enamel and bone). If the pineal accumulates fluoride at an earlier age than in previous decades, one would anticipate that a high local concentration of fluoride within the gland pineal could affect the functions of the pineal gland, ie, the synthesis of hormonal products, specifically melatonin ... the controlled animal study conducted in this study products convincing evidence that fluoride inhibits pineal melatonin production during pubertal development in the gerbil. "
SOURCE: Lucas J. (1997) The effect of fluoride on the pineal gland physiology Ph.D. Thesis, University of Surrey, Guildford pag 168-169

[ fluoride and Pineal - early puberty in animals:

"the section on the effects of fluoride on physiological signs of sexual maturity in the gerbil was a preliminary pilot study. There were not enough subjects to draw firm conclusions so the interpretation of the data is conjecture. However, the results suggest that the HF (High-Fluorine) women had a rapid onset of puberty, judging by several indices of pubertal development in rodents at 7 weeks, the HF females were significantly heavier than females low frequency (p <0.004) ;. as heavy as the HF males and LF males. ventral gland HF female developed significantly earlier than the female LF (p <0.004). vaginal opening occurred early female high frequency in the LF female (p <0 .03=".03" br="br"> SOURCE:.... Luke J. (1997) The effect of fluoride on the pineal gland physiology Ph.D. Thesis University Surrey, Guildford pag 173-174

fluoride and Pineal -...? in early puberty in humans

"the first step in the evaluation of a health risk for a substance to humans is the identification of its harmful effects on animals. a risk to the health of humans was assessed using the results of epidemiological studies in humans, in relation to the results of animal studies. the Newburgh-Kingston study (Schlesinger et al, 1956) showed an earlier age of first menarche in girls living in the Newburgh fluoridation in unfluoridated Kingston. the study on current animal indicates that fluoride associated with an earlier onset of puberty in female gerbils. In addition, it was recommended more research on the effects of fluoride on animal and human reproduction (Public Health Service, 1991). the project has brought new knowledge in this area. "
SOURCE: Lucas J. (1997) The effect of fluoride on the pineal gland physiology Ph.D. Thesis, University of Surrey, Guildford p 177.

...... fluoride and Pineal - Mechanism of action:

"the most plausible explanation for the significant observed in the rate of aMT6s urinary excretion by the HF (High-fluoride) group decreased hypothesis is that fluoride affects ability to synthesize the pineal melatonin during pubertal development in the gerbil. Fluorine can affect the enzymatic conversion of tryptophan to melatonin. although melatonin hormone investigated in this project, fluoride can also affect the synthesis of the precursors of melatonin, (e.g., serotonin), or other pineal products (for example, 5-methoxytryptamine) . this will depend on the position (s) of the enzyme (s) capable. For some unknown reason, pineal calcification starts intracellularly. calcium has been shown in pinealocyte mitochondria. Therefore, it can be a mitochondrial enzyme which is sensitive to the effects of fluoride, for example, tryptophan hydroxylase-5. Alternatively, the fluoride may affect pinealocyte enzymes that require divalent coenzyme because such enzymes are particularly sensitive to fluoride. "
SOURCE: Lucas J. (1997) The effect of fluoride on the pineal gland physiology Ph.D. Thesis, University of Surrey, Guildford pag 172-173

[ fluoride and Pineal - Discussion:

"fluoride is now introduced at a much earlier stage of human development than ever and thus alters the pharmacokinetics fluorides in normal infants

But you can dramatically increase the normal intake of fluoride babies and get away with it? The safety of the use of fluorides ultimately is based on the assumption that the developing enamel organ is most sensitive to the toxic effects of fluoride. The results of this study suggest that pinealocitos can be as susceptible to fluoride as the developing enamel organ. The possibility of a species difference between humans and gerbils does not allow extrapolation of the data gerbil humans. However, if the increased plasma levels of fluoride cause a decrease in circulating melatonin levels during early human development, may have important physiological consequences already occurred. Changes in plasma concentrations of melatonin are severe functional disturbances because melatonin has many functions in the body. The pinealogists have not completely unraveled the mechanisms by which the pineal gland perform its functions in the brain. The neurochemical phenomenon caused by melatonin in the CNS are unclear.

The first step in evaluating a health risk for a substance to humans is the identification of its harmful effects on animals. A health risk to humans was assessed using the results of epidemiological studies in humans, in relation to the results of animal studies. The Newburgh-Kingston Study (Schlesinger et al, 1956) showed an earlier age of first menarche in girls living in fluoridated Newburgh in Kingston without fluoridation. The current study on animals indicates that fluoride is associated with an earlier onset of puberty in female gerbils. Moreover, further research is recommended on the effects of fluoride on animal and human reproduction (USPHS 1991). This project has brought new knowledge in this area.

I do not intend to discuss the relative merits of the claims made by the anti-fluoridationists that chronic ingestion of low levels of fluoride has harmful effects on health human, ie, increases the risk of cancer, affects the immune system and accelerates the aging process. These statements may be associated with the effects of fluoride in the pineal because the gland has been linked to oncogenesis, immunocompetence, and, in recent years, with the aging process.

In conclusion, the gland human pineal contains the highest concentration of fluoride in the body. Fluoride is associated with the pineal melatonin synthesis by prepubertal gerbils depressed and accelerated onset of sexual maturation in the female gerbil. The results support the hypothesis that the pineal has a role in the time of onset of puberty. Whether or not fluoride interferes with pineal function in humans requires further investigation "
. SOURCE: Luke J. (1997) The effect of fluoride on the physiology of the pineal gland Ph.D. thesis.... University of Surrey, Guildford pag 176-177

Source:... fluoridealert.org

"Fluoride & the Pineal Gland", article source: riseearth.com

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