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Title : Anti Smoking Vaccine- To Be a Reality Soon!
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Anti Smoking Vaccine- To Be a Reality Soon!

people, who have in the past tried to quit various means, but a relapse will be happier with the news of an anti smoking vaccines NicVAX- can hit the markets soon. This vaccine anti-snuff designed to help people quit smoking, has entered phase III clinical trials that, when successful, will pave the way for the fight against injectable drug smoking to enter the market , most likely next year.
How NicVAX Works?
NicVAX stimulates the immune system to produce antibodies that bind nicotine in the bloodstream and causes the nicotine molecule too large to cross the barrier system blood-brain and enter the brain. Once inside the brain, nicotine causes the release of dopamine, a chemical associated with pleasure and addiction. NicVAX ultimately prevents the pleasure that keeps people addicted to snuff consumption and other uses of nicotine. During clinical trials with the vaccine and placebo conducted by nine different institutions, including the University of California who helped half of smokers to quit. During the second phase of the trials, participants were vaccinated six times and now 80 percent gave up. Unlike nicotine replacement treatments, NicVAX not enter the brain, and therefore does not have the same adverse psychological effects such as depression or suicidal thoughts associated with other treatments.
The vaccine that limits the ability of nicotine to enter the brain gives smokers the opportunity to fight to end the addiction and the cycle of relapse. "Phase III Trial of nicotine vaccine offers tremendous hope towards solving this immense problem of public health," said Dr. Francis Collins, director of the National Institutes of Health (NIH) has awarded $ 10 million the American Recovery and Reinvestment Act to fund NicVAX phase III trial.
Nabi Biopharmaceuticals and GlaxoSmithKline Association
The manufacturer of the vaccine against smoking NicVAX - Nabi Biopharmaceuticals- has entered into a partnership with the pharmaceutical company GlaxoSmithKline Biologicals to develop the vaccine using Nabi's intellectual property. GSK may choose to exercise its option to develop and commercialize NicVAX as soon well as closing the deal, which is expected to occur in the first quarter of 2010, or wait until the first phase III results are available, which is expected in the second half of 2011 the successful completion of phase III trials will bring NicVAX vaccine closer to final approval by the FDA. Based on initial tests successfully, the FDA has already received the designation of NicVAX "fast track" for final testing and approval.

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