Title : Fatty Liver (Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis)
link : Fatty Liver (Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis)
Fatty Liver (Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis)
Data on non-alcoholic liver disease
disease nonalcoholic} discomfort (non-alcoholic liver disease, NASH) is the accumulation of abnormal amounts of fat liver intervals.
} disease nonalcoholic disease is divided into isolated liver disease in which there is only fat accumulation, and soft steatohepatitis (NASH) within which there fat, inflammation and damage to the liver cells.
NASH progresses to scarring and ultimately to cirrhosis of the liver, with all the complications of cirrhosis of the liver, for example, duct epithelial damage, liver failure and liver cancer.
The development of mild disease} disease is closely related to and is perhaps caused by the meatiness and polygenic disease.
disease nonalcoholic disease} is taken into account a manifestation of metabolic syndrome.
Symptoms unit area} mild disease especially those of the complications of cirrhosis of the liver in patients with NASH disease; isolated occasionally liver disease causes symptoms and usually discovered by chance. Complications of cirrhosis of the liver include:
Gastrointestinal (GI) pain
Mental changes (encephalopathy)
The accumulation of fluid (ascites, edema)
Liver cancer
Differentiation isolated liver disease writer usually needs a diagnostic assay liver.
The most promising for diseases unit area mild disease}
diet treatments
exercise
weight loss, and
possibly bariatric surgery.
Various drugs are studied in the treatment of the writer. there is very little evidence that any drug is effective in the firmness of the progression discomfort writer.
Many unit related to writer and unit area of a part of the metabolic syndrome diseases area. These diseases should be examined and treated, for example, the level of high pressure, dyslipidemia and polygenic disease.
isolated liver disease rarely progresses to cirrhosis or liver writer.
} nonalcoholic disease disease and affects young young writer also.
NASH can be one of the reasons for the amount of liver transplantation unless the area unit found effective and safe treatments.
What is the disease of liver disease?
Fatty liver may be a condition in which the liver cells redoubled abnormally accumulate fat quantities. although excessive alcohol consumption could be a very common reason for liver disease (NAFLD), there is another type of liver disease, called mild illness} disease (nonalcoholic liver disease), in which alcohol has been excluded as cause. Disease in mild disease}, different known causes of liver disease less common unit that alcohol causes surface are excluded.
} disease nonalcoholic disease could be a manifestation of metabolic abnormalities associated with liver intervals. The liver is a vital organ in the metabolism (handling) fat. The liver produces and exports different elements fat body. It also removes fat from the blood that has been discharged by different tissues within the body, for example, by fat cells, or absorbed from foods that tend to eat. In mild disease disease}, fat handling by liver cells is disturbed. redoubled unit amounts of fat area outside the unit of blood and / or area produced by the liver cells, and is not enough to be transferred or exported by cells. As a result, fat accumulates in the liver.
} disease nonalcoholic disease is classified as either liver disease (sometimes referred to as isolated liver disease or IFL) or steatohepatitis (NASH). In each writer associated disease isolated liver there is an abnormal amount of fat in liver cells, but additionally writer for swelling at intervals liver, and as a result, the unit area of the liver cells broken die, and unit area replaced by connective tissue.
Why is the disease} important mild disease?
disease disease nonalcoholic} is vital for many reasons. First, it is a typical discomfort, and is increasing in prevalence. Second, the writer is a fundamental reason for serious illness, resulting in liver cirrhosis and complications of cirrhosis - liver failure, duct epithelial damage, and liver cancer. mild disease diseases} Third, related to different fairly common and heavy non-liver disease, perhaps the most important to be vital upset that ends in heart disease and stroke. liver disease, most likely is not the reason for these different diseases, however could be a manifestation of the underlying cause associated diseases that have in common. liver disease, therefore, could be an indication of the presence of these various serious illnesses that require to be self-directed
What causes mild liver disease?
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The reason for the mild disease and advanced disease} is not fully understood. the most important vital factors seem to be the presence of intensity and polygenic disease. Meatiness are accustomed thought that was nothing easier fat accumulation in the body. Fatty tissues are believed to be inert, ie it merely served as fat storage sites and had very little activity or interactions with different tissues. they tend to stop now that fat tissue is extremely active metabolically and has interactions and effects on tissues throughout the body.
When huge amounts of drive fat gift area, since we are in meatiness, fat becomes metabolically active (actually inflamed) and gives rise to the assembly of many hormones and proteins that unit area expressed in blood and have effects on cells throughout the body. one in each of the many effects of these hormones and proteins is hypoglycaemic market resistance in cells.
insulin resistance could be a state in which the body's cells do not respond adequately to hypoglycemic agent, an endocrine gland that produces exocrine. hypoglycemic is vital, as a result of a serious promoter aldohexose uptake (sugar) from the blood by cells. At first, the exocrine gland compensates for the inability to hypoglycemic by creating and much emotional hypoglycemic agent, however, finally, now will not leave large amounts of hypoglycemic agent and, indeed, could begin supplying decreasing amounts. At the time, not enough sugar enters the cells, and begins to accumulate in the blood, a condition called polygenic disease. although the blood sugar is present in huge amounts, inability to hypoglycemic prevents cells get enough sugar. Since sugar is a vital source of energy for cells and allows them to wait for their specialized functions, shortage of sugar begins to change the medium in which cells carry out.
In addition to the emotional and protein hormones, fat cells also begin to disengage number of fat being kept within them the type of fatty acids. As a result, there is an increase in blood levels of fatty acids. This can be of vital importance as a result of huge amounts of insurance unhealthful type of unit cells area fatty acids.
The release of hormones, proteins and fatty acids from fat cells affects cells throughout the body in various ways in which. Liver cells, as several different cells in the body, become resistant hypoglycemic agent, and its metabolic processes and their fat handling, become altered. Liver cells increase their absorption of fatty acids blood wherever unit area fatty acids in abundance. at intervals of liver cells, the unit area fatty acid became fat storage, and fat accumulates. At the same time, the flexibility of the liver to remove or export stored fat is reduced. In addition, the liver itself continues to supply the fat and for dietary fat. The result is that fat accumulates an excellent larger measure.
What unit of the opposing causes of fatty liver area?
There are many unit area of the placeable disease causes} that does not seem like the mild disease of liver disease but might cause confusion. The main unit common area of excessive alcohol consumption and hepatitis C. embody different causes
upset Wilson
lipodystrophy (an upset fat storage)
hungry
the intravenous nutrition, and
abetalipoproteinemia (an upset of transporting fat).
Various medications also cause of liver disease, including
corticosteroids
tamoxifen (Nolvadex), and
methotrexate (Rheumatrex, Trexall).
What unit of the signs and symptoms of fatty liver area?
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Fatty liver unwellness {|} disease rarely causes symptoms until liver disease is much more advanced. liver disease normally found or suspected when:
unit area of abnormal liver tests found in blood tests routine
Fat is once ultrasound imaging of the abdomen performed for different reasons, for example, the designation of gallstones
infrequently once the liver is enlarged on physical examination of a patient
When the disease is more advanced (cirrhosis), signs and symptoms of cirrhosis of the liver predominate. These include:
excessive pain as a result of liver failure to form proteins blood clotting
Jaundice as a result of the failure of the liver to remove hematoidin blood
pain gastrointestinal result of malignant hypertension increasing the pressure in the enteric blood vessels
the accumulation of liquid as a result of malignant hypertension that causes fluid leakage from blood vessels and also the failure of the liver to form the supermolecule whole blood, albumin
mental changes (encephalopathy) as a result of the inability of the liver to remove chemicals from the body to the brain unit insalubrious area. coma may occur.
Liver cancer
What is the difference between mild liver disease and steatohepatitis (NASH)?
As it mentioned background, the distinction between single disease, liver and steatohepatitis soft (NASH) is that the presence of inflammation and damage to the liver cells in NASH; in each, the liver has redoubled amounts of fat. although some third of the final population have liver disease, about 100 percent have writer. about one third of patients with mild disease have writer diseases}. although liver disease and writer seem to come down to similar conditions, it seems that liver disease progresses writer. Therefore, if a patient is the development of liver disease compared with the writer set awfully early-wide accumulation of fat, although it is unclear what factors verify this. it is believed that inflammation and damage of the surface unit of liver cells caused by unhealthy effects of fatty acids expressed by fat cells, however fatty acids within the unit area of elevated blood in each disease liver and writer. perhaps the distinction is explained by genetic condition as recommended by foreknowledge.
The consequences of fat in the liver depend largely on the presence or absence of inflammation and liver damage, that is, whether there is or is not fat alone or writer's gift. isolated liver disease does not reach vital disease. NASH, on the opposite side, progress through the formation of the scar (fibrous tissue) to liver cirrhosis. Complications of cirrhosis of the liver, primarily through epithelial damage, liver failure and liver cancer, then could occur.
What is the link between mild disease} disease, obesity and diabetes?
As mentioned background, pterygium and polygenic disease have a vital role in the development of liver disease. While a third of the final population (including corpulent and people with diabetes) could develop the disease} mild disease, more than two thirds of people with diabetes {| polygenic disorder | unwellness polygenic} develop mild liver disease. Among patients terribly big unit and undergoing surgery area WHO for meatiness, most of the diseases are mild disease}. Furthermore, while the danger of writer is fewer than five hits among thin people, the danger has passed a third between burly. liver disease prevalence increase in each well as gravity because the degree of increase fleshiness. The start will increase the weights unit area of thought on overweight -. It is, but burly
What is the link between mild disease} disease and metabolic syndrome?
Metabolic syndrome could be a syndrome described by the association of many metabolic abnormalities that create unit area of owning a typical cause. These metabolic abnormalities lead to
Obesity
triglycerides elevated blood,
low density high conjugated protein (HDL) sterol,
high pressure level, and
elevation blood glucose (diabetes).
disease nonalcoholic disease} is taken into account a manifestation of metabolic syndrome and it happens often with opposing manifestations of the syndrome. sometimes it must occur while not opposing anomalies syndrome.
How is the disease diagnosed mild disease}?
As mentioned history, liver disease usually causes no symptoms or signs and symptoms and signs unit area of a large number of possible result for concomitant diseases such as pterygium, diabetes, vascular discomfort, etc. In either with fleshiness or polygenic disease, liver disease should be suspected. in a time very few patients, unit area of abnormal liver tests found in routine blood tests, although anomalies typically smooth surface unit. in all likelihood, the common methodology especially that soft} disease is the disease is diagnosed by imaging studies such as image, CAT (CT) and nuclear magnetic resonance (NMR); the unit area obtained for reasons other than illness} mild disease designation. } mild disease disease, also also discovered once patients develop complications of the disease - cirrhosis of the liver, liver failure and liver cancer -. as a result of the presence of writer
is unattainable to differentiate between liver disease and isolated writer imaging studies. through a mixture of many blood tests have been recommended as a method to separate the 2 and unit test area are being developed for the writer to eat, diagnostic test liver is that the best suggests to differentiate between the presence fat or fat and inflammation (NASH) no. although most people may have isolated liver disease and not a writer, which is vital to detect patients with writer, thanks to the obligation to report to complications of the disease and to enter these patients in treatment trials hoping to prevent disease progression. Patients with metabolic syndrome, obesity, and the unit area polygenic disease leading candidates intelligent diagnostic test liver since the incidence of the writer is greater between these teams.
One difficulty writer designation because of severe scarring or reason cirrhosis of the liver is due to scarring of the liver cirrhosis progresses, fat disappears. This results in a condition that is referred to as cryptogenic cirrhosis of the liver, cirrhosis of the liver in which there is no clear cause. (Specifically, cryptogenic cirrhosis of the liver the 2 most common causes of liver cirrhosis - alcohol and hepatitis -. Not seem concerned) cryptogenic Cirrhosis of the liver has baffled doctors for several years in their cause. However, at present it seems that half cryptogenic cirrhosis of the liver that occurs in patients with intensity and / or polygenic disease and possibly is as a result of writer.
What is the treatment for mild liver disease?
Treatment for the disease of mild disease} includes
changes in lifestyle (exercise, weight loss, diet),
drugs
supplements (antioxidants )
The omega-3 fatty acids
surgery, and
liver transplant.
The fatty liver and diet
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disease nonalcoholic disease} has been associated in studies with humans or animals with small amounts of unsaturated fats (a diet high in saturated fat) and redoubled amounts of cetohexosa (which is the most commonly added value to the diet such as corn syrup, high fructose). acceleration edges of unsaturated fat (low saturated fat diet, and better unsaturated fat) and reducing high ketohexose syrup on diseases} mild disease have not been shown; but, there is little harm in doing so, especially since there are also edges of these changes in non-liver-related diet.
An interesting observation - although "without explanation - is that there is less scarring (fibrosis) in the livers of patients with writer who drink more than 2 cups per day low. (Scarring or pathology is that the method that ultimately results in liver cirrhosis.) Similar Bordes low are related to a lower degree of disease in each alcoholic cirrhosis of the liver and hepatitis C. is not unreasonable to advocate drinking milk low in moderate amounts in view of the lack of adverse effects of the facet.
Vitamin D deficiency is associated with mild disease disease}. although there is no reason to suppose that this deficiency contributes to disease mild disease}, it is cheap to live calciferol levels in patients with mild disease and treat diseases} with calciferol if they are deficient.
There is no evidence of the harmful effects of alcohol sol (two or fewer drinks per day for men, one for women) in mild disease} disease but 'there is also no evidence that It is safe! Large amounts of alcohol should be avoided around the world as well as people with mild disease disease}.
The fatty liver, weight loss and exercise
Because severe complications of the unit} area mild disease seen primarily in patients with writer, disease treatment important writer is nice. unfortunately there is no clearly effective treatment for these patients. one in each of the difficulties distinguishing effective treatments is that the lack of long-term studies, and writer progression to liver cirrhosis and its complications occurs slowly. Many treatments have resulted in a reduction of fat in the liver very however few have shown that progression is slowed writer.
Weight loss and exercise unit area between the main promising treatments for diseases} mild disease. Not huge amounts of weight loss needed to lead to a decrease in liver fat. A decrease but 100 weight percent is sufficient. Vigorous exercise ends at a discount of fat in the liver and also could slow the inflammation of the writer. The long-term effects of weight loss and exercise on the vital development of liver cirrhosis and its complications unknown unit area. still, at present, the simplest theoretical approach to disease} mild disease is weight loss and strenuous exercise. unfortunately, only a minority of patients unit area ready to perform these.
The drugs and the different treatment options
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insulin sensitizers
Metformin (Glucophage) could be a drug used to treat polygenic disease. Its function is to increase the sensitivity of cells hypoglycemic, hypoglycemic directly counter resistance that accompanies the disease mild disease} also because metabolic syndrome. which has been studied yet, unfortunately, it not has been clearly found to boost liver injury associated with the writer.
Pioglitazone (Actos) and rosiglitazone medication unit area (Avandia) used to treat polygenic disease as a result of that increase sensitivity hypoglycemic agent. There have been a discount fat in the liver and signs of liver damage with each drug, and pioglitazone can cut the scarring that results from inflammation of the writer. Two problems that occur with the treatment area of weight gain and unity, rosiglitazone, an increase in heart attacks. Pioglitazone is also used to treat NASH; but we must recognize that they have not been well established efficacy and long term safety.
Antioxidants
Vitamin E has been studied in writer thanks to its general effects of inflammation opposite. It has been shown to reduce fat and liver inflammation and presumably pathology, however its effectiveness and long-term safety have not been well studied. Moreover, treatment of patients with fat-soluble vitamin that have writer is related to the following mortality. fat-soluble vitamin is used to treat writer, however, it is used by the selection (not all patients said), and patients should perceive the potential risk.
Pentoxifylline
The pentoxifylline (Trental) has been studied for the treatment of writer in small groups of patients with encouraging results; but there is not enough experience or data on safety and efficacy to promote treatment outside analysis studies.
The omega-3 fatty
acids
Small studies have shown some benefit with omega-3 fatty in reducing fat in the liver in mild disease} disease, and larger unit area studies afoot. Giant teams of people (not elected by the presence or absence of mild liver disease), it was shown that omega-3 fatty acids to cut deferential events like heart attacks and overall mortality. Therefore, the omega-3 fatty acids is also acceptable treatment for patients with mild disease} disease and metabolic syndrome as a result of these patients have a high incidence of discomfort and death.
lipid-lowering medication
Lipid lowering drugs, statins and ezetimibe specifically (Zetia), are used to treat abnormal blood lipids associated with metabolic syndrome. although there is no evidence of effect of drugs in the liver in mild disease} disease, not enough experience to advocate for them in patients with mild disease} disease, unless they are mainly getting used to treat abnormal blood lipids .
The ursodeoxycholic acid
The ursodeoxycholic acid (Ursodiol) has been studied in mild disease} disease however, has been abandoned by her helplessness and considerations of toxicity at high doses terribly.
Bariatric surgery
Bariatric surgery is surgery of the digestive tract that ends in weight loss, and there are many unit area different types of bariatric surgery. Since fleshiness is believed to be a vital thought about the exploit of the disease} mild discomfort and weight loss has been shown to have useful effects in mild liver disease, it is not surprising that bariatric surgery has been thought about as a possible treatment for disease} mild disease. Only one study has as the consequences of bariatric surgery on soft} disease disease and has incontestable that fat and decreasing inflammation and smooth progression of pathology for a lot of severe disease is inactive. (Patients with a lot of serious were not studied pathology and therefore is not recognized if the progression of a lot of serious pathology is also inactive.) Still, as a result of acceptable studies to develop each of the benefits and risks of bariatric surgery have not been done, was advised that bariatric surgery should not be used as a treatment for the writer. Instead, patients should be elected for surgery regardless of the presence or absence of a writer.
Liver transplantation
Once a cirrhotic liver has become and there have been complications, options for unit area of treatment, whether the treatment of complications that may arise or to exchange the pathological liver with a liver transplant. In fact, the writer has become the third most common for liver transplant, only to alcoholic disease and hepatitis C reason, however is expected to climb to the number one position as a result of the epidemic of intensity and polygenic disease is occurring within the US unfortunately, the writer is often repeated in the transplanted liver so it progresses to liver cirrhosis, presumably as a result of the underlying causes - meatiness and polygenic disease -. continue
What is the link between mild disease} disease and vessel disease?
As mentioned background, upset, particularly heart attacks and strokes, they are often seen in patients with liver disease. In fact, the causes of the death of a large amount of glass frequency related deaths occur liver.
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