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Title : Scientists Have Managed To Edit HIV Out Of Infected Cells
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Scientists Have Managed To Edit HIV Out Of Infected Cells

id = " In recent years have seen a huge leap in terms of genome editing. With the development of the technique of CRISPR amazing / Cas9, scientists have never been able to identify easily and accurately, edit or delete specific sections of DNA. This has enabled scientists point to particular mutations, giving hope that the cure of certain inherited diseases could be around the corner. Now, researchers have used to guide HIV, and have managed to eliminate the virus genome of infected cells. When HIV infects someone, its RNA is transcribed in HIV-1 DNA, which is integrated below in a cell of the specific immune system known as CD4 + T cells. This means that infected cells then replicate the HIV genome, producing more virus, which can then go to infect more CD4 + T cells. This has the effect of weakening the immune system and eventually leads to acquired immunodeficiency syndrome, or AIDS, then with patients usually succumbing to other diseases such as pneumonia beatable. Current antiretroviral drugs aim to prevent the virus from infecting cells in the first place, but once the virus has placed its DNA into T cells, there is little that can be done, and infected cells then act, in effect, as a reservoir for HIV. "Antiretroviral drugs are very good at controlling HIV infection," says Kamel Khalili, principal investigator of the study published in Scientific Reports. "However, patients on antiretroviral therapy who stop taking the drugs undergo rapid recovery in HIV replication." Therefore, the team of the Health System of Temple University instead decided to see if they could use the impressive accuracy of CRISPR to locate and remove sections of DNA derived from HIV-infected T cells . They showed that they were actually able to remove the entire HIV genome without other side effects into host cells, which continue to grow and divide normally. Not only that, but already eradicated HIV T cells were then immune to the new virus infection later. "The findings are important on several levels," says Dr. Jalili. "They demonstrate the effectiveness of our editing system genes in removing HIV from DNA of CD4 T cells and, by introducing mutations into the viral genome, which permanently inactivates replication. They also show that the system you can protect cells from reinfection and that the technology is safe for cells without toxic effects. " significantly, the researchers conducted experiments with CD4 + T cells taken from patients infected HIV and then cultured in the laboratory, giving hope that the technique could be improved to such an extent that doctors are no longer simply stop the infection of cells, but heal them.
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