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Title : Beating Human Hearts Grown In Laboratory Using Stem Cells
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Beating Human Hearts Grown In Laboratory Using Stem Cells

id = " At this time, there are 4,186 people waiting for a heart transplant in the US. UU., but with a huge shortage of donors not all of these patients are likely to survive. The growing transplantable hearts in a laboratory has been a long-held dream within the medical community, and a study in the journal Circulation Research has moved a step closer to reality: A team of researchers has successfully grown a human heart beating in the laboratory using stem cells. Previous research has shown that 3D printers can be used for manufacturing segments, 3D heart using biological material. Although vacancy of any real heart cell, these structures provide the "scaffold" on which it could grow heart tissue. Now a team of both the Massachusetts General Hospital (MGH) and Harvard Medical School has taken this concept combined with scaffolds and stem cells for some really spectacular results. The main problem of heart transplants, other than the lack of donors, is there a chance that the recipient's body from rejecting the new organ. Your immune system often register the foreign tissue as a threat, after which they proceed to attack and destroy it. The only way to prevent this from happening are drugs that suppress the immune system, and this is only successful in some cases. For this study, 73 human hearts considered suitable for transplantation were immersed in detergent care solutions in order to deprive them of any cell that cause this self-destructive response. What remained was a matrix (or "scaffold") of a heart, with their intricate structures and vessels, providing a new basis for new heart cells to be cultured. This is where the pluripotent stem cells These come in "primitive" stem cells have the ability to become almost any cell type in the body, including the bones, nerves, muscles and even - Including .. those found in the heart for this study, human skin cells were reprogrammed to become pluripotent stem cells. They were then induced to become two types of heart cells, which were to develop and grow in the laboratory scaffold when bathed in a nutrient solution easily.
After just two weeks, networks of cells cultured heart in laboratory and resembled immature hearts, but intricate structure. The team gave a burst of light, and his heart started beating really. Significantly, cells cultured heart in this way would be recognized by the immune system of the patient as "friendly" as long as the cells of the original skin came from his own body in the first place. This means that these hearts grown in the laboratory, would not be rejected and, of course, do not expect to donors. "Among the next steps that are taking place are improved methods to generate heart even more cells," said Jacques Guyette, a biomedical researcher at the Center for Regenerative Medicine at MGH and lead author of the study said in a statement. Although this study produced a whopping cardiac cells derived from stem cells 500 million for the procedure, re-grow an entire heart actually have "tens of billions" added Guyette. So despite falling below growing all human, mature heart in a laboratory from patients' own cells, this is the one closest has come so far to achieve this goal - . And that in itself is an impressive
achievement (source)

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