Title : If You Have Any of These Symptoms, Stop Eating Gluten Immediately (you may Have celiac disease!)
link : If You Have Any of These Symptoms, Stop Eating Gluten Immediately (you may Have celiac disease!)
If You Have Any of These Symptoms, Stop Eating Gluten Immediately (you may Have celiac disease!)
First, let's mention that only a small group of people (who are genetically predisposed to celiac disease), you can actually develop this health condition. However, the real reasons for its occurrence have been unclear. A group of medical experts say it may be down to how certain intestinal bacteria respond to gluten. What is celiac disease? Celiac disease is an immune disease in which a person is intolerant to gluten. Gluten is the protein found in grains, including rye, wheat and barley. According to the latest statistics, nearly 1% of the American suffer from this disease.
This is what happens - when a person with celiac disease eat foods containing gluten, the immune system responds by damaging the small intestine. This can lead to abdominal pain, diarrhea, bloating and fatigue, among other symptoms. Medical experts say that certain genetic mutations are known to trigger celiac disease. However, only 2-3% of people who have such mutations will actually develop the disease.
These are the most important about celiac disease facts:
- About 83% of Americans celiac disease are undiagnosed or misdiagnosed with other conditions
- the only existing treatment for celiac disease is a gluten-free diet
- About 5-22% of people with celiac disease they have a first-degree relative with the disease.
Dr. Elena F. Verdu (principal investigator), Institute of Digestive Health Research at McMaster University in Canada, was looking the main reason for this disease. Dr. Elena and colleagues looked at how the immune response to gluten varied with different populations of intestinal bacteria in mouse models of gluten intolerance. The results of this study were published in The American Journal of Pathology.
Medical experts examined mice, divided into three groups - which express a gene called DQ8, which are found in humans and makes genetically susceptible to gluten intolerance. Each group of mice had different compositions intestinal bacteria or intestinal microbiome. One group was free of germs, while another group was clean specific pathogen free (SPF); their gut microbiome were free of proteobacteria - a group of gram-negative bacteria - and opportunistic pathogens. And the last group consisted of conventional SPF mice, which had a wide range of intestinal bacteria, including Proteobacteria and opportunistic pathogens such as Staphylococcus, Streptococcus and Helicobacter.
All mice were subjected to gluten, and the results were as follows:
Medical experts each group of mice exposed to gluten. They researchers found that the germ-free mice showed increased intraepithelial lymphocytes (IEL) in the intestine increases; IEL proliferation and activation is an early indicator of celiac disease. Increased levels IEL, however, not observed in the clean SPF mice. And the germ-free mice experienced increased death of the cells lining the gastrointestinal tract, enterocytes calls along with anatomical abnormalities of small fingerlike projections, lining the small intestine, known as the villi.
It can also be noted that researchers also identified the development of antibodies in response to a component of gluten - called gliadin - between germ-free mice, and these mice also showed responses of T cells specific for this component . Dr. Elena and her team also found that the development of the pathology induced by gluten stopped in SPF mice compared to clean germ-free mice, but this was not the case when the SPF mice received clean enter Escherichia coli adherent of a patient with celiac disease.
Medical experts have also found that conventional SPF mice showed increased pathology induced by gluten that clean SPF mice, the researchers said, so the team set out to investigate whether the presence of the Proteobacteria, such as Escherichia and Helicobacter, plays a role. In the increased presence of proteobacteria between conventional SPF mice by administration of an antibiotic called vancomycin at the time of his birth, the researchers found that the gluten-induced disease worsened. Specifically, the team identified increased levels IEL.
Dr. Elena Verdu said
"These studies demonstrate that disruption of microbial colonization early in life and induction of dysbiosis (imbalance microbial inside the body), characterized by increased Proteobacteria, improves the severity of the responses induced by gluten in mice genetically predisposed to gluten sensitivity. importantly, our data argue that the increased prevalence recognized celiac disease in the general population over the last 50 years could be driven, at least in part, by disturbances in the intestinal microbial ecology. specific therapies based on the microbiota can help in the prevention or treatment of celiac disease in patients with moderate genetic risk. "
The famous Dr. Robin G. Lorenz of the University of Alabama at Birmingham, said that although these findings suggest the presence of proteobacteria can play an important role in the pathology of celiac disease, proteobacteria not mean that causes the disease. One alternative suggests, is that somehow proteobacteria reinforce the immune response to gluten or gliadin. Another, more recent study has found that people with celiac disease may have an increased risk of nerve damage. This study was published by Medical News. Thanks for reading and do not forget to share this article with your friends and family.
Source / reference: familylifegoals.com
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