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Title : Oral bacteria linked to risk of stroke
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Oral bacteria linked to risk of stroke

id = " brain researcher and his Japanese collaborators demonstrate the importance of oral health in stroke

in a study of patients admitted to hospital for acute stroke, researchers


Robert P. Friedland, MD have increased their understanding of an association between certain types of stroke and the presence of oral bacteria ( CNM-positive Streptococcus mutans) . Robert P. Friedland, MD, C. Mason and Mary D. Rudd Chair and Professor of Neurology at the University of Louisville School of Medicine, was co-author of the study, published online this month in the scientific reports , a journal of the Nature Publishing Group. The study hospital alone, researchers at the Cardiovascular Center in Osaka, Japan and cerebral National, patients with stroke observed to gain a better understanding of the relationship between hemorrhagic stroke and oral bacteria. Among patients who had intracerebral hemorrhage (ICH), it was found that 26 percent have a specific bacteria in their saliva, S. mutans CNM-positive . Among patients with other types of stroke, only 6 percent tested positive for the bacteria. Strokes are characterized as either ischemic strokes, which involve a blockage of one or more blood vessels supplying the brain, or hemorrhagic strokes, in which blood vessels in the rupture of the brain, causing bleeding. The researchers also evaluated MRIs of study subjects for the presence of brain microhaemorrhages (CMB), small brain hemorrhages that can cause dementia and also often the basis of the ICH. They found that the number of CMBS was significantly higher in subjects with S. mutans CNM-positive than in those without. The authors hypothesize that S. mutans bacteria can bind to blood vessels weakened by age and high blood pressure, causing arterial ruptures in the brain, resulting in small or large hemorrhages. "This study shows that oral health is important for brain health. People have to take care of their teeth, because it is good for your brain and your heart as well as your teeth," Friedland said . " The study and related work in our laboratories have shown that oral bacteria are involved in various types of stroke, including brain hemorrhages and strokes that lead to dementia." Multiple research studies have shown a close association between the presence of gum disease and heart disease, and a 2013 publication by Jan Potempa, Ph.D., D.Sc., Faculty of Dentistry UofL revealed how the bacteria responsible for gum disease worsens rheumatoid arthritis. The S. mutans CNM-negative bacterium is found in about 10 percent of the general population, Friedland says, and is known to cause tooth decay (caries). Friedland is also investigating the role of oral bacteria in other diseases that affect the brain. "We are investigating the role of oral bacteria and the gut at the onset of pathology in neurodegenerative disorders Alzheimer's and Parkinson's collaborators in the UK and Japan."

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