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Title : Apple Extract Kills Colon Cancer Cells Better Than Chemotherapy Drug
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Apple Extract Kills Colon Cancer Cells Better Than Chemotherapy Drug

Recent studies have found that the natural compounds called oligosaccharides derived from apples, killed up to 46 percent of cancer cells in vitro human colon, and overcame the chemotherapy drug most commonly used by a wide margin at all dose levels tested. And unlike toxic chemotherapy drugs, oligosaccharides are natural compounds that promote health widely present in fruits and vegetables.

A natural solution for a leading cause of cancer death?

Colon cancer is currently the second leading cause of cancer-related death for women worldwide and the third leading cause for men. The standard chemotherapy drug used care for colon cancer has been limited success, and can have serious side effects such as coronary spasm, neurotoxicity, anemia and immunosuppression. The researchers focused on apples as a natural means for treatment and prevention of colon cancer, as they are the most consumed fruit in many countries, and have demonstrated activity against breast cancer, ovarian cancer, lung cancer , liver cancer and colon cancer. oligosaccharides Apple were used in this study because of its anticancer properties have been established in previous studies , and that can be derived cheap apple pulp - a waste product widely available surplus industry apple juice processing.


Oligosaccharide Apple are more effective drug chemotherapy to destroy COLON CANCER cells

Researchers at the University in Xi'an, China isolated polysaccharides (pectin and other fibers apple pulp) and treated natural pectinase to break its molecules into oligosaccharides more small (only they have three to ten sugar units per molecule). The oligosaccharides were then added to cancer cells Cultured human HT29 colon at various concentrations, and compared with the chemotherapy drug most commonly used for colon cancer.

For each concentration tested, oligosaccharides exceeded the chemotherapy drug in the induction of programmed cell death (apoptosis). For example, only 0.9 micrograms per ml (about 0.9 ppm), oligosaccharides killed 17.6 percent of colon cancer cells after 36 hours, while the chemotherapy drug only killed 10 , 9 percent (in a higher concentration of 1.3 micrograms per ml). More importantly, because apple oligosaccharides are not toxic to healthy cells, they can be used at higher concentrations than is possible with the chemotherapy drug. 9.0 PPM, oligosaccharides killed 46 percent of colon cancer cells (the chemotherapy drug was not tested at this level).


OLIGOSACCHARIDES - FUNCTIONAL FOODS WITH MULTIPLE HEALTH BENEFITS

Oligosaccharides have been gaining increasing attention recently as functional foods that promote health in general, and are probably used to enrich various foods and eat (ie, as fructooligosaccharides). They have been found in studies to promote healthy intestinal flora, control blood sugar, and modulate the immune system. Oligosaccharides occurring naturally in many plants (fruits, vegetables and seaweed), as well as honey and milk. Also they may be formed by decomposition of carbon hydrates complex fruit (i.e. pectin) by pectolytic enzyme as by researchers in this study was made. To some extent, this reaction can also occur by eating raw fruit, since apples naturally contain 1.5 percent pectin and pectinase enzyme. However, it should be noted that apple juice commercially processed more enzymes contains virtually no pectin or assets, and also contains only about 10 percent of health-giving polyphenols compared with raw apples. As usual, eating raw and fresh is much healthier than consuming the processed version.

This new study adds more evidence of beneficial health effects of apples and potent anti-cancer effects of their oligosaccharides, even at low concentrations. The fact that these oligosaccharides can be derived from a waste product widely available industry apple juice (about four million tons of pomace produced annually) offers the promise of a natural medicine inexpensive in the future.

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