Title : Popular Drugs That Increase the Risk of Dementia Even at Low Dosage
link : Popular Drugs That Increase the Risk of Dementia Even at Low Dosage
Popular Drugs That Increase the Risk of Dementia Even at Low Dosage
A recent study by the University of Washington gave strong evidence that some popular drugs may increase the risk of dementia in the elderly.
All these drugs showed the same mechanisms within the key areas in the brain, and are mainly used as ingredients in nonprescription prescription cough, cold dream and allergies as well as treatment of depression and overactive bladder .
Drugs and dementia
The most popular drugs connected to dementia are those containing diphenhydramine. It is used in several products known as Nytol Sominex, Benadryl, Triaminic Allergy, Theraflu, and many others.
Other drugs used in the study were chlorpheniramine (Aller-chloro); tolterodine (Detrol); and oxybutynin (Ditropan) for overactive bladder; and tricyclic antidepressants such as amitriptyline or doxepin.
reference data
Acetylcholine is an essential for memory and cognitive function neurotransmitter. For example, Alzheimer's disease is connected to the drastic reduction of the levels of this neurotransmitter, as a result of the reduction of the activity of choline acetyltransferase, the enzyme producing acetylcholine.
The fact that there is a connection between low levels of acetylcholine and dementia, among other poor brain function, researchers did previous studies linking some medicines for the activity of low acetylcholine and cognitive impairment mild. These drugs include the above.
Although it is considered that the suspension of the drug reverses mental deficiency, it was found that anticholinergic drugs can cause permanent changes that result in irreversible dementia.
It is known that these drugs cause drowsiness short-term or confusion, as stated in the prescribing information. However, their long-term effects on mental function are generally unknown to doctors and patients taking them.
Other drugs associated with risk of dementia in relief are antihistamines and sedative hypnotics ( sleeping pills ). Older adults use these drugs, both prescription and over the counter types, at an alarming rate, putting them at serious risk of dementia.
New data
Researchers have studied the medical records of 3,434 participants age 65 or older who did not have dementia, in order to determine whether the use of cumulative anticholinergic is linked to increased risk of incident dementia. The initial recruitment occurred 1994-1669 and from 2000 to 2003, but the analysis also included data until 30 September 2012.
anticholinergic exposure is determined from computerized pharmacy records. Participants were followed for a period of 10 years, and their cumulative exposure are continuously updated. It was found that about 20% of them use anticholinergic drugs.
During this period, 23.2% of participants (797) developed dementia, and 80% of these (637 participants) developed Alzheimer's disease. It was noted that the cumulative dose-response relationship for the period of 10 years compared with Alzheimer's disease and dementia. It was found that the cumulative anticholinergic use, the higher the risk of dementia. For example, a person will reach the level of heaviest exposure if s / he took any day of anticholinergic agents for more than 3 years period.
The study results are worrisome, and the researchers propose a greater effort to raise awareness among older adults and care professionals about the risk that long-term use of these drugs. Chronic use of these drugs, even at low doses should be avoided.
Conclusion
In this study the dangers of long-term use of these types of medications, such as Benadryl and over-the-counter sleeping pills are indicated. the use of natural methods instead of these drugs, which have proved to successfully address the key problem (allergies, insomnia, etc.), while at the same time a positive effect on brain function is suggested.
For example, isoquercitrin (CIMS) is an enzymatically modified natural compound that has been shown to have adequate anti-allergic effects, while blocking the formation of the protein considered to participate in the development of brain damage in Alzheimer's disease called beta amyloid.
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