Title : Brazilian Wasp Venom Kills Cancer Cells, But Not Healthy Cells!
link : Brazilian Wasp Venom Kills Cancer Cells, But Not Healthy Cells!
Brazilian Wasp Venom Kills Cancer Cells, But Not Healthy Cells!
Id = " Wasps have their fair share of bad press. They have painful stingers, and are not as useful (or mono) to us like bees. However, their residence time in the spotlight may be just around the corner :. Its venom has been shown to attack cancer cells while leaving healthy cells
toxin targeting cancer wasp called MP1 (Polybia-MP1 ) and so far, how cancer cells is selectively removed was not known. According to new research, which exploits the unusual arrangement of fats or lipids in the cell membranes of cancer. His abnormal distribution creates weak points where the toxin can interact with lipids, which ultimately looks huge holes in the membrane. These are large enough for molecules essential to start filtering out, like proteins, the cell can not function without. The responsible for the production of this toxin wasp is Polybia Paulista . The toxin has so far been tested in model membranes and examined using a wide range of imaging techniques. You can see the results of the investigation team in the Biophysical Journal.
Brazilian Avispa The wasp, Polybia Paulista, which It produces poison containing MP1. Professor Mario Palma / Sao Paulo University. "cancer therapies that attack the lipid composition of the cell membrane would be an entirely new class of cancer drugs," said Paul Beales at the University of Leeds and co-author the study. "This could be useful in developing new combination therapies, where multiple drugs are used to treat cancer simultaneously attacking different parts of cancer cells at the same time." In healthy cell membranes, the inner layer (into the cell) is filled with phospholipids, including PS (phosphatidylserine) and PE (phosphatidylethanolamine). However, in cancer cells, PS and PE are found in the outer layer of the cell membrane, facing the opposite way. To test the different effects of the presence of PS and PE in a cell, scientists examined how the MP1 interacted with model membranes infused with PE and / or PS. The presence of each phospholipid had a destructive effect on cells. PS MP1 increases the likelihood of binding to the membrane by a factor of seven to eight. The presence of PE inflates the size of the holes created by the MP1 by a factor of 20 to 30.
"Formed in seconds, these large pores are large enough to allow critical molecules such as RNA and protein cells escape easily, "Ruggiero said João Neto Sao Paulo State University and co-author of the study. "The dramatic improvement induced permeabilization peptide in the presence of PE and size of the pores of these membranes was surprising."
The next stage of this research is to adjust the amino acid sequence of MP1 to see what gives its selective properties, and to try to improve them. "Understanding the mechanism of action of this peptide in translational studies will help to better assess the potential of this peptide to be used in medicine," says Beales. "As demonstrated to be selective to cancer cells and is not toxic to normal cells in the laboratory, this peptide has the potential to be safe, but more work would be necessary to prove."
(source)
Thanks for Reading Brazilian Wasp Venom Kills Cancer Cells, But Not Healthy Cells!
Thank you for reading this Brazilian Wasp Venom Kills Cancer Cells, But Not Healthy Cells!, hopefully can give benefits to all of you. well, see you in posting other articles.
You are now reading the article Brazilian Wasp Venom Kills Cancer Cells, But Not Healthy Cells! Url Address https://healthnbeautyarticles.blogspot.com/2016/06/brazilian-wasp-venom-kills-cancer-cells.html
0 Response to "Brazilian Wasp Venom Kills Cancer Cells, But Not Healthy Cells!"
Post a Comment