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Title : Scientists Have Found A Way To Make Cancer Cells Kill Each Other
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Scientists Have Found A Way To Make Cancer Cells Kill Each Other

The laboratory team discovered some unusual effects of antibodies in bone marrow cells during their work on treatments for certain cells immune deficiencies or blood factors. They wanted to find antibodies that activate receptors of growth factors in cells of immature bone marrow, ie, to find antibodies that will grow in these cells specific types of blood cells.

Some of the antibodies were found as activators of bone marrow cell receptors, had surprising effects on cell- he realized investigators. Some of the cells transformed into something completely different from what was thought, since neuronal cells. Researchers began to wonder whether this method could be used to change cells from bone cancer (leukemia cells) in healthy cells.

Transformation

Lita Annenberg Hazen Professor of Immunochemistry at TSRI and Richard A. Lerner, school teacher made a team with some colleagues, along with the first author Kyungmoo Yes, assistant professor of cell and molecular biology of TSRI professor. They took cells from AML patients and 20 human antibody receptor activator recently in developing leukemia cells tested. The results showed that of the antibodies had amazing effect on cancer cells.

thrombopoietin (TPO) receptor is found in most cells of acute myelogenous leukemia and activates this receptor in bone marrow cells. Cells were grown in cells producing blood platelet (megakaryocyte) when the antibody is inserted into the healthy marrow. Furthermore, when the antibody is inserted into cells of acute myeloid leukemia dendritic cells become very important for the immune system cells.

This discovery was a great success because cancer cells became healthy, beneficial for the immune system cells. The study went further and found that if the antibodies and other regulated conditions were already acting, dendritic cells matured further. a group of cells formed ultimately they were quite similar to natural killer cells (NK). these cells to attack the potentially dangerous pathogens and tumors are made, as they are defenders of the immune system

"This antibody those cells of acute myeloid leukemia could have become a lot of other cell types, but somehow we had enough to NK cells, "Lerner said luck.

'Fratricide'

were observed

NK cells by electron microscopy and was a source of hectares have several unique features. These cells contain tentacles extend that succeeded in finding their way through the outer membranes of cells closely leukemia -by - cells so still there if not inserted the antibody. The laboratory test showed that a large number of NK cells turned against their former brethren, but a small number of NK cells defeated about 15 percent of leukemia cells in the vicinity within 24 hours.

Purely fratricide nature of NK cells was observed by researchers. They do not attack the cells of breast cancer in many unrelated as was the case of leukemia cells related. The researchers found why NK cells act this way, but there is a possibility that there are other undiscovered antibodies that will transform cancer cells into NK cells.

This type of therapy is called "fratricidins" by Lerner and allegedly has several advantages. These antibodies would be beneficial with little or no adjustments and high specificity of NK cells the probability of damaging healthy cells is reduced. That is why treatment "fratricidins" is safer than traditional treatments such as chemotherapy.

In theory all cancer cells can be transformed so that the ultimate goal is to find a treatment that will not only reduce the cancer cells, but to eliminate them completely.

"is a completely new approach to cancer, and we are working to test in human patients as soon as possible," Lerner said. "We are in talks with pharmaceutical companies to take this directly to humans after appropriate preclinical toxicity studies."

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