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Title : Radiation Therapy Can Make Cancers 30x More Malignant
link : Radiation Therapy Can Make Cancers 30x More Malignant

Radiation Therapy Can Make Cancers 30x More Malignant

by Sayer Ji
GreenMedInfo

Following in the footsteps of recent revelations that mammography x rays may be contributing to an epidemic of subsequent breast cancers induced by radiation, in a new article entitled, " radiation Treatment Generates stem cell therapy resistant cancer from aggressive cells of breast cancer ", published in the journal 1st cancer July 2012, researchers at the Department of radiation Oncology in the report of the UCLA Jonsson Comprehensive cancer Center that radiation treatment really drives the cells of breast cancer increased malignancy .

the researchers found that even when the radiation kills half of treated tumor cells, the surviving cells that are resistant to treatment, known as mother induced breast (iBCSCs) cancer cells were to 30 times more likely to form tumors cell non-irradiated breast cancer. In other words, the radiation treatment backs the total population of cancer cells, creating the false impression that the treatment is working, but actually increases the ratio of highly malignant from benign cells within the tumor, eventually leading to iatrogenic (induced treatment) the patient's death.


last month, a related study published in the journal Stem Cells entitled, "radiation-induced breast cell reprogramming," he found that ionizing radiation reprogrammed cancer cells (differentiated) less malignant breast iBCSCs, which helps explain why the conventional treatment actually enriches the tumor population with higher levels of resistant cells to treatment . [ i ]

A growing body of research now accuses conventional cancer treatment with chemotherapy and radiation as one of the leading causes of mortality of patients Cancer. The main reason for this is the fact that cancer stem cells, which are almost entirely resistant to conventional treatment, are not targeted, but on the contrary, are encouraged to thrive when exposed to chemotherapy and radiotherapy.

in order to understand how conventional treatment boosts cancer in greater malignancy, we must first understand what cancer ....

What are CSCs and why they are resistant to treatment?

Tumors are highly organized in sets of cells actually are surprisingly well coordinated cells are assumed to be the result of a mutation strictly random. They are able to build their own blood supply (angiogenesis), are able to defend gene silencing suppression of cancer, which secrete corrosive to freely move throughout the body enzymes, altering their metabolism live in low oxygen and acidic environments and know how to remove their own surface proteins receivers to avoid detection by white blood cells. In a previous article entitled " is the program for Cancer Survivorship A former unmasked? " have delved deeper into this emerging view of cancer as a throw-back evolutionary and not a product of mutation strictly to chance.

Because tumors are not simply the result of one or more mutated cells "going rogue" and production of exact clones of itself (hypothesis of multiple mutations and clonal), but they are a diverse group of cells that have radically different phenotypic characteristics, chemotherapy and radiation affect each cell of a different type.

Tumours are composed of a wide range of cells, many of which are entirely benign.

the type deadliest cell cancer tumor or blood, known as cancer stem (CSC) cells, have the ability to give rise to all cell types found within that cancer.

they are able to divide by mitosis to form either two stem cells (increasing the size of the stem population), or a daughter cell passing differentiate into a variety of cell types, and a daughter cell retaining properties of stem cells.

This means that the CAC are tumorigenic (tumor formation) and should be the primary goal of cancer treatment, as they are able to both initiate and sustain cancer. is also increasingly recognized to be the cause of relapse and metastasis after conventional treatment.

CSCs are exceptionally resistant to conventional treatment for the following reasons

1. the CCC represent less than 1 in 10,000 cells within a given type of cancer, making them difficult to destroy without destroying the vast majority of other cells comprising the tumor. [ II ]
2. CSCs are slow to replicate, making them less likely to be destroyed by chemotherapy and radiation treatments that target cells that are dividing more quickly.
3. conventional chemotherapies target differentiated and differentiating cells, which form the bulk of the tumor, but they are unable to generate new cells as the CSC that are undifferentiated.

The existence of cancer stem cells explains why conventional cancer treatment has completely lost the boat when it comes to targeting the root cause of the tumors. One reason for this is because existing cancer treatments mostly developed in animal models, where the goal is to reduce tumor size. Because mice are the most used and their life cycles not exceeding two years, tumor relapse is very difficult if not impossible to study.

The first round of chemotherapy does not kill all tumor, but only a percentage. This phenomenon is called fractional killing. The aim is to use repeated cycles of treatment (usually six) to regression of the tumor to zero population without killing the patient.

What usually happens is that treatment selectively kills less harmful populations of cells (daughter cells), increased the proportion of cancer the malignant cells and benign / or less stem cells. This is not unlike what happens when antibiotics are used to treat certain infections. The drug can kill 99.9% of the target bacteria, but 0.1% have or develop resistance to the agent, allowing 0.1% to return even stronger with time.

Antibiotic also kills other beneficial bacteria that help the body fight infections naturally in the same way that chemotherapy kills the patient's immune system (white blood cells and bone marrow), ultimately, support the underlying conditions that make recurrence of the most likely disease.

the reality is that chemotherapy, although it has been reduced tumor volume, by increasing the proportion of stem cells benign cancer cells to daughter cells, has actually made the cancer more malignant.

Radiation therapy It has also been shown to increase cancer stem cells in the prostate, resulting in cancer recurrence and worse prognosis. [ iii ] cancer stem cells could also explain why castration therapy often fails in the management of prostate cancer. [ iv ]

non-toxic natural substances that attack and kill cancer stem cells

natural compounds have been shown to exhibit three properties that make them suitable to conventional chemotherapy and radiotherapy alternatives:

1. high safety margin: regarding chemotherapy agents such as 5-fluorouracil natural compounds are the two orders of magnitude safer
2. selective cytotoxicity the ability to target only those cells that are cancerous and healthy cells
3. targeting cancer stem cells :. The ability to target cancer stem cells in a tumor population

The main reason why these substances are not used in conventional treatment is because they are unpatentable, or profitable . Unfortunately, the criteria for selection of drugs are not safety, effectiveness, accessibility and affordability. If this were so, it would be natural compounds form an integral part of the standard of care in the treatment of modern cancer.

Research indicates that the following compounds (along with common sources of food) have the ability to target CSCs:

1. curcumin (turmeric)
2. resveratrol (red wine, Japanese knotweed)
3. quercetin (Onion)
4. sulforaphane (sprouts Brocolli)
5. Parthenolide (Butterbur)
6. Andrographalide (Andrographis)
7. genistein (cultured soy, coffee)
8. piperine (pepper Black)

further investigation is on page GreenMedInfo.com multidrug resistance indicate more than 50 compounds inhibit cancers multidrug resistance in experimental models.

reprogramming breast cancer cells [i] radiation induced. Mother cells. 2012 May; 30 (5): 833-44. PMID: 22489015
[ii] human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997 Jul.; 3 (7): 730-7. PMID: 9212098
[iii] The long-term recovery of prostate cancer increases irradiated cancer stem cells. Prostate. Epub 18. April 2012. 18. April 2012. PMID: 22513891
[iv] Like the mother with luminal progenitor phenotype Surviving Castration in human prostate cancer cells. Mother cells. 2012 Mar 21. Epub 2012 Mar 21. PMID: 22438320

"Radiation Therapy Can Make Cancers 30x More Malignant", article source: riseearth.com

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