Title : Research: Natural Treatments for Ebola Virus Exist
link : Research: Natural Treatments for Ebola Virus Exist
Research: Natural Treatments for Ebola Virus Exist
CNN reports , 'Ebola outbreak could have "catastrophic consequences "."Given the statistics prevailing mortality, perhaps fear is, at least partially justified, with the most virulent form of the virus - Zaire, Ebola virus - notes that have a mortality rate of around 83%, [1] without officially recognized conventional or natural therapy that is able to mitigate the morbidity and mortality associated with infection of the same.
Actually, there are five Ebola virus in the genus Ebola virus [2] with four of they are known to infect humans causing disease virus Ebola, a highly lethal form of hemorrhagic fever.
infection by the Ebola virus is believed to originate from either monkeys or fruit bats, and once a human being is infected, transmission can occur through blood or body fluids, sexual intercourse, [3] and as recent relative research report revealed through the air.
While conventional medical system reflexively puts his faith and money in developing drugs and vaccines, with NIH recently announced that will begin early one trial vaccine Ebola this month September this year, very little research has been conducted on the risk reduction or mitigate damage after infection, using approaches immune stimulation and / or based on time-tested and plants.
Given the low security risk and cost of botanical- based interventions in food, this is where we look first for viable and affordable solutions immediately.
Indeed, a recent study published in 2012 holds great promise in terms of identifying a natural way to attenuate virulence - and therefore also the widespread fear -. Associated with the Ebola virus
Published in the journal Archives of Virology and entitled, " Inhibition of Lassa virus and infection with the Ebola virus into host cells treated with genistein inhibitors kinase and tyrphostin ", researchers at the University of Texas Medical Branch, investigated the potential therapeutic role of two called" kinase inhibitors "in interfering with Ebola virus:
1) genistein compound the plant.
2) tyrophostin pharmaceutical drug
Reference to the authors of a study in previous animals showing genistein was able to reduce the damage from the infection of a virus that causes Ebola fever such as hemorrhagic viral (VHF) in hamsters (ie, the Pichinde (PICV) virus), report the results as follows:
"infection of hamsters with pIRV produces manifestations of VHF, including inflammation / lesions in various organs, increased core temperature, weight loss, viremia, petechiae, bleeding, and mortality.The researchers sought to determine the genistein and the ability to tyrophostin to inhibit viral entry of several viruses that cause Ebola hemorrhagic fever, including Marburg virus (MARV), vesicular stomatitis virus (VSV) and Lassa virus (LASV). proteins these four viruses were designed to be expressed by a special type of virus known as vesicular stomatitis virus (VSV).
" Treatment of animals with genistein kinase inhibitor led to a significant increase in survival and to improve the signs of VHF disease [9].
"None of the treated animals showed mock-infected adverse signs of diseases associated with treatment. therefore, this study served as a proof of concept for the use of a kinase inhibitor as a therapeutic or prophylactic in an animal model ". [emphasis added]
the study found both genistein and tyrophostin individually inhibit entry of these viruses in cells both through interference with endocytosis (the process by which a cell strip in a virus) and uncoating proteins (the process by which a virus alters proteins on the surface of the host cell to gain entry) .
It was also observed that there was a synergistic effect when genistein and tyrophostin were added together.
The researchers analyzed the results:
"In total, these data demonstrate that infection of host cells with MARV and EBOV filovirus and LASV arenavirus is inhibited when cells are pretreated with genistein or tyrphostin AG1478. in both cases, inhibition was found to be concentration dependent.genistein where does it come from?
"Although inhibition EBOV in cells pretreated with 100 lM genistein seemed slightly different, the addition of increasing concentrations of tyrphostin AG1478 led to a synergistic antiviral effect.
"in total, these data demonstrate that inhibitors cocktail kinase consisting of genistein and tyrphostin AG1478 can act as a wide antiviral against EBOV, MARV, and LASV in vitro. " [emphasis added]
While it is mainly found in soy products, soy foods especially fermented, in which beneficial microbes cause biotransformation of phytocompund genistein precursor in genistein, is also found in beans, kudzu, coffee and red clover and many other lesser known medicinal plants.
What else does genistein?
In Greenmedinfo.com indexed over 150 have health benefits of genistein, through 50 assigned physiological pathways, have been identified in the biomedical literature.
You can see here: based on the evidence Benefits genistein . It is interesting to note that the broad-spectrum antiviral properties of genistein have already been identified. A 2009 review [4] in fact, he stated:
"Genistein is, by far, the isoflavone most studied in this respect soybeans, and has been shown to inhibit the infectivity of enveloped viruses or not wrapped and RNA viruses or DNA single or double stranded.What other therapeutic agents Natural potential for Ebola?
"at concentrations ranging from physiological supraphysiological (3.7 to 370 MUM), flavonoids, including genistein, has shown to reduce the infectivity of a variety of viruses that affect humans and animals, including adenovirus, herpes simplex virus, HIV, porcine reproductive and respiratory syndrome virus and rotavirus. "
First, it should be noted that, historically, Ebola virus outbreaks occur in some of the poorest places Earth (mainly the poorest regions of Africa), among chronically malnourished populations traumatized by socio-political instability and wars, and where today sanitation, hygiene practices and proper nutrition, suboptimal are available , to say the least.
in other words, does not seem to predict an outbreak of the 'catastrophic' call in the US and other countries rich media to take into account the different contexts which causes infections such possible to begin with the "internal terrain", ie the host immune fundamental in determining the degree to which an individual becomes susceptible to infection.
said, the Ebola appears to be a pathogenic virus uniquely to the human body, however, it has had enough time to properly adjust time, and therefore it is instructive to note other potential natural therapies have he studied in the past:
Garcinia kola: As reported in 1999 , it was found that extracts of the seeds of this African traditional medicinal herb to "inhibit this virus ... [Ebola] in cell culture to non-toxic concentrations. "
Vitamin C: According to the deceased Dr. Robert Cathcart, MD , which had extensive experience in the treatment of life-threatening infections with high doses of vitamin C, "Ebola virus kills mode free radicals that can be neutralized by massive doses of sodium ascorbate intravenously."
Indeed, Ebola virus disease - such as viral haemorrhagic disease in general - characteristics of acute scurvy resembles, and Vitamin C is well known for having a wide range of benefits , including immune-stimulating and antiviral properties with a very high safety margin.
homeopathic interventions: A study published in 1999 explored the therapeutic potential of a homeopathic preparation spider venom six eyes (Sicarius) in the treatment of symptoms associated with Ebola infection [5] virus [
Estradiol a 2,013 analysis, entitled " a systematic screen drugs approved by the FDA for inhibitors threat agents biological , "he found that estradiol displayed against Ebola activity in vitro virus, indicating the importance of hormonal factors and perhaps gender in susceptibility to disease - as well as a possible therapeutic role for estradiol if future clinical research confirms these findings carried out
.
this is only a small sample, and the fact is that very little research has been done in this area.
A wide range of natural compounds that have yet to be evaluated for its anti-Ebola direct activity and / or properties immune boosting, and can be of great importance for the purpose of the prevention and cure of the same.
The most important consideration is that there is no infection - including highly lethal as Ebola - occurs in a vacuum.
The whole psychological, biological, environmental and socio-political factors determine the incidence, spread and virulence of viral infections.
Therefore, in the absence of any method or based vaccine known to prevent or reduce the harmful effects of Ebola infection drugs, the aforementioned research and environmental considerations '' can provide hope and address future to deal with such epidemics.
This is especially important considering how deeply fearful people have become the spectrum of diseases that do not understand -. Fears that contribute to immunosuppression and therefore may contribute to fulfilling prophecy associated with belief in the extreme lethality of Ebola
By Sayer Ji Green Med Info ;
References:
[1] Isaacson, M; Sureau, P; Courteille, G; Pattyn, SR;. Clinical Aspects of Ebola virus disease in Ngaliema Hospital, Kinshasa, Zaire, 1976 . Retrieved 2009-07-08.
[2] Kuhn, J. H.; Becker, S.; Ebihara, H.; Geisbert, T. W.; Johnson, K. M.; Kawaoka, Y.; Lipkin, W. I.; Negredo, A. I.; Netesov, S. V.; Nichol, S. T.; Palacios, G.; Peters, C. J.; Tenorio, A.; Volchkov, V. E.; Jahrling, P. B. (2010). " Proposed revised taxonomy Filoviridae family: classification, the names of the taxa and viruses, and abbreviations of virus ". Archives of Virology 155 (12): 2083-2103. doi: 10.1007 / s00705-010-0814-x. PMC 3074192. PMID 21046175.
[3] " Ebola virus disease Fact sheet No. 103 ". World Health Organization. March 2014. Accessed April 12, 2014.
[4] Aline Andres, Sharon M Donovan, Mark S Kuhlenschmidt. Soy isoflavones and virus infections. J Nutr Biochem. 2009 Aug; 20 (8): 563-9. PMID: 19596314
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